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Laba ama afar irbadood oo balaasmaha qani ku ah platelet ee jilibka osteoarthritis ma bedelin biomarkers synovial, laakiin sidoo kale waxay hagaajiyeen natiijooyinka caafimaad

Marka loo eego tijaabada khubarada warshadaha ee ku habboon, waxay isbarbar dhigeen laba iyo afar irbado gudaha articular ah oo Plasma-hodan ah (PRP) marka loo eego isbeddelada cytokines synovial iyo natiijooyinka caafimaad.125 bukaan oo qaba osteoarthritis-ka jilibka (OA) ayaa la siiyay irbado PRP 6dii toddobaadba mar.Kahor duritaanka PRP kasta, rabitaanka dareeraha synovial ayaa loo ururiyay daraasad.Bukaan-socodka ayaa loo qaybiyay laba ama afar irbadood oo gudaha ah oo PRP ah (kooxaha A iyo B, siday u kala horreeyaan).Isbeddellada biomarkers synovial ayaa la barbardhigay heerarka aasaasiga ah ee labada kooxood, iyo natiijooyinka kiliinikada ayaa la qiimeeyay ilaa hal sano.Sagaashan iyo afar bukaan oo dhameeyay ururinta dareeraha synovial ayaa lagu daray qiimayntii ugu dambaysay, 51 ee kooxda A iyo 43 ee kooxda B. Ma jiraan farqi u dhexeeya da'da celceliska, jinsiga, index mass index (BMI), iyo darajada shucaaca OA.Tirada celceliska platelet iyo tirada unugyada dhiiga cad ee PRP waxay ahaayeen 430,000 / µL iyo 200/µL, siday u kala horreeyaan. -4, IL-10, IL-13, iyo IL-1RA) isma beddelin, iyo Qodobbada koritaanka (TGF-B1, VEGF, PDGF-AA iyo PDGF-BB) waxay ahaayeen saldhigga aasaasiga ah iyo inta u dhaxaysa toddobaadyada 6 ee kooxda A iyo 18 toddobaad Kooxda B. Natiijooyinka kiliinikada ee labada kooxood ayaa si aad ah uga soo fiicnaaday toddobaadyadii 6, oo ay ku jiraan Muuqaalka Analog Miisaanka (VAS), Tallaabooyinka Natiijooyinka La Soo Sheegay ee Bukaanka [PROMs;Western Ontario iyo Jaamacadaha McMaster Osteoarthritis (WOMAC) Tusmada iyo Foomka Gaaban-12 (SF-12)], cabbirada waxqabadka ku salaysan [PBMs;waqtiga la kaco (TUG), 5 sit-stand tests (5 × SST), iyo 3-daqiiqo imtixaanada socodka (3-daqiiqo WT)) Gabagabadii, 2 ama 4 irbado gudaha articular ee PRP 6 toddobaad kasta jilibka OA ma muujin wax isbeddel ah oo ku yimid cytokines synovial iyo arrimaha koritaanka, laakiin sidoo kale waxay hagaajisay natiijooyinka bukaan-socodka laga bilaabo 6 toddobaad ilaa 1 sano.


Waqtiga boostada: Mar-03-2022