Androgenic alopecia (AGA), nooca ugu badan ee timaha daataan, waa cillad timo lumis ah oo horumarsan oo ka bilaabata qaan-gaarnimada ama qaan-gaarnimada dambe.Baahsanaanta ragga ee waddankeyga waa qiyaastii 21.3%, tirada dumarku waa qiyaastii 6.0%.Inkasta oo culimada qaarkood ay soo jeediyeen tilmaamo loogu talagalay ogaanshaha iyo daaweynta alopecia androgenetic alopecia ee Shiinaha waagii hore, waxay inta badan diiradda saaraan ogaanshaha iyo daaweynta AGA, iyo fursadaha kale ee daaweynta ayaa ka maqan.Sannadihii ugu dambeeyay, iyada oo xoogga la saarayo daaweynta AGA, qaar ka mid ah ikhtiyaarrada daaweynta cusub ayaa soo baxay.
Etiology iyo Pathogenesis
AGA waa cillad hidde-socod ah oo soo noqnoqota polygenic.Sahannada cudurrada faafa ee guduhu waxay muujinayaan in 53.3%-63.9% bukaannada AGA ay leeyihiin taariikh qoys, khadka aabbahana aad ayuu uga sarreeyaa khadka hooyada.Isku-daba-joogga-genome-ga hadda jira iyo daraasaadka khariidadeynta ayaa aqoonsaday dhowr hiddo-sideyaal u nuglaadaan, laakiin hidde-sidaha cudur-sidaha weli lama aqoonsan.Cilmi-baarista hadda waxay muujineysaa in androgens ay door muhiim ah ka ciyaaraan pathogenesis ee AGA;arrimo kale oo ay ka mid yihiin bararka agagaarka timaha follicle, cadaadiska nolosha oo kordhay, kacsanaanta iyo welwelka, iyo nolol-xumada iyo caadooyinka cunto cuniddu waxay sii xumeyn kartaa calaamadaha AGA.Androgens ee ragga inta badan waxay ka yimaadaan testosterone oo ay soo daayaan xiniinyaha;androgens ee haweenka inta badan waxay ka yimaadaan synthesis of adrenal cortex iyo xaddi yar oo dheecaan ka ugxan-sidaha, androgen inta badan waa androstenediol, kaas oo la metabolized karaa testosterone iyo dihydrotestosterone.Inkasta oo androgens ay yihiin arrin muhiim ah oo ku saabsan pathogenesis ee AGA, heerarka wareegga androgen ee ku dhowaad dhammaan bukaannada AGA ayaa lagu hayaa heerar caadi ah.Daraasaduhu waxay muujiyeen in saamaynta androgens ee timaha u nugul ay korodho sababtoo ah korodhka muujinta hidda-wadaha soo-dhoweynta iyo / ama korodhka muujinta nooca II 5α reductase ee timaha timaha ee aagga alopecia.Waayo, AGA, unugyada maqaarka maqaarka ee follicles timaha u nugul waxaa ku jira nooc gaar ah II 5a reductase, kaas oo u bedeli kara testosterone androgen ku wareegaysa aagga dhiigga in dihydrotestosterone by xidhi in receptor androgen intracellular.Bilaabida falcelin taxane ah oo horseeda yaraynta horumarka timaha follicle-ka iyo timaha oo daataan bidaarta.
Tilmaamaha Kiliinikada iyo Talooyinka Daaweynta
AGA waa nooc ka mid ah alopecia aan nabar lahayn oo inta badan bilaabma xilliga qaan-gaarka waxaana lagu gartaa khafiifinta dhexroorka timaha, luminta cufnaanta timaha, iyo alopecia ilaa heerar kala duwan oo bidaar ah, badanaa waxaa weheliya calaamadaha kor u kaca dheecaanka saliidda madaxa.
Codsiga PRP
Xoojinta platelet waxay u dhigantaa 4-6 jeer fiirsashada platelet ee dhiiga oo dhan.Marka PRP la hawlgeliyo, granules α ee platelets waxay sii deyn doonaan tiro badan oo ah arrimo koritaan, oo ay ku jiraan factor koritaanka platelet, beddelka factor koritaanka-β, factor koritaanka insulin-sida, factor koritaanka epidermal iyo vascular endothelial factor factor, iwm. ee kor u qaadida koritaanka timaha follicle, laakiin habka gaarka ah ee ficilku si buuxda uma cadda.Isticmaalka waa in lagu duro PRP gudaha lakabka maqaarka madaxa ee alopecia, bishiiba mar, iyo irbado joogto ah 3 ilaa 6 jeer waxay arki kartaa saameyn gaar ah.Inkasta oo cilmi-baaris caafimaad oo kala duwan oo gudaha iyo dibedda ah ay si horudhac ah u xaqiijiyeen in PRP ay saameyn gaar ah ku leedahay AGA, ma jirto halbeeg isku mid ah oo loogu talagalay diyaarinta PRP, markaa heerka wax ku oolka ah ee daaweynta PRP maaha mid la mid ah, waxaana loo isticmaali karaa caawiye. macnaheedu waa daawaynta AGA marxaladdan.
(Qoddobada maqaalkan dib ayaa loo daabacay, mana bixinno dammaanad cad ama dammaanad dhab ah oo sax ah, isku halaynta ama dhammaystirnaanta waxa ku jira maqaalkan, mas'uulna kama aha fikradaha maqaalkan, fadlan fahan.)
Waqtiga boostada: Agoosto-02-2022