Shaqada Jirka ee Platelet

Platelets (thrombocytes) waa qaybo yaryar oo cytoplasm ah oo laga sii daayo cytoplasm ee Megakaryocyte ee baaluq ee dhuuxa lafta.Inkasta oo Megakaryocyte ay yihiin tirada ugu yar ee unugyada hematopoietic ee dhuuxa lafta, oo lagu xisaabiyo kaliya 0.05% tirada guud ee unugyada nukleed ee dhuuxa lafta, platelets ay soo saaraan waxay aad muhiim ugu yihiin shaqada hemostatic ee jirka.Megakaryocyte kasta wuxuu soo saari karaa 200-700 platelets.

Tirada platelet-ka ee qaangaarka caadiga ah waa (150-350) × 109/L.Platelets waxay leeyihiin shaqada ilaalinta sharafta derbiyada xididdada dhiigga.Marka tirada platelet ay hoos u dhacdo 50 × Marka cadaadiska dhiiggu uu ka hooseeyo 109/L, dhaawac yar ama cadaadis dhiig oo kordha ayaa sababi kara dhibco dhiig oo istaaga maqaarka iyo xuubka hoose, iyo xitaa purpura weyn.Tani waa sababta oo ah platelets waxay degi karaan derbiga xididada xididdada wakhti kasta si ay u buuxiyaan godadka ka soo baxa unugyada endothelial, waxayna ku dhex milmi karaan unugyada xididada xididada, kuwaas oo laga yaabo inay door muhiim ah ka ciyaaraan ilaalinta sharafta unugyada endothelial ama hagaajinta unugyada endothelial.Marka ay jiraan tiro yar oo platelet ah, hawlahani way adagtahay in la dhammaystiro waxaana u janjeera dhiigbax.Platelet-ka ku jira dhiigga wareegaya guud ahaan waxay ku sugan yihiin xaalad “joog ah”.Laakiin marka xididdada dhiigga ay dhaawacmaan, platelets waxay ku hawl galaan taabashada dusha sare iyo ficilka arrimo xinjirowga qaarkood.Platelets-ka firfircooni waxay sii deyn karaan maadooyin taxane ah oo lagama maarmaan u ah habka hemostatic iyo jimicsi hawlaha jireed sida xabag, isku-darka, sii-deynta, iyo adsorption.

Platelet ee soo saara Megakaryocyte sidoo kale waxaa laga soo qaatay unugyada tarma ee hematopoietic ee dhuuxa lafta.Unugyada asliga ah ee Hematopoietic waxay marka hore u kala soocaan unugyada hore ee megakaryocyte, oo sidoo kale loo yaqaano colony forming unit megakaryocyte (CFU Meg).Koromosoomyada ku jira xudunta u ah marxaladda unugyada hore waa guud ahaan 2-3 ploidy.Marka unugyadu yihiin diploid ama tetraploid, unugyadu waxay awood u leeyihiin inay bataan, markaa tani waa marxaladda marka khadadka Megakaryocyte ay kordhiyaan tirada unugyada.Markii unugyadii hore ee megakaryocyte ay sii kala sooceen 8-32 ploidy Megakaryocyte, cytoplasmku wuxuu bilaabay inuu kala saaro nidaamka Endomembrane si tartiib tartiib ah.Ugu dambeyntii, walaxda xuubku waxay u qaybisaa cytoplasm ee Megakaryocyte meelo yaryar oo badan.Marka unug walba uu si buuxda u kala go'o, wuxuu noqdaa platelet.Mid mid, platelets waxay ka soo dhacaan Megakaryocyte iyaga oo sii maraya farqiga u dhexeeya unugyada endothelial ee derbiga sinuska ee xididdada waxayna galaan qulqulka dhiigga.

Lahaanshaha sifooyin difaac oo kala duwan.TPO waa glycoprotein inta badan ay soo saaraan kelyaha, miisaankooduna yahay 80000-90000.Marka platelets ee dhiigga ku jira hoos u dhacaan, xoogga TPO ee dhiigga ayaa kordha.Hawlaha qodobkan sharciyeynta ah waxaa ka mid ah: ① kor u qaadista DNA-ga ee unugyada hore iyo kordhinta tirada polyploids-ka unugga;② Kicin Megakaryocyte si ay u soo saarto borotiinka;③ Kordhi wadarta tirada guud ee Megakaryocyte, taasoo keentay korodhka wax soo saarka platelet.Waqtigan xaadirka ah, waxaa la rumeysan yahay in fidinta iyo kala-soocidda Megakaryocyte ay inta badan nidaamiyaan laba arrimood oo nidaamsan oo ku saabsan labada marxaladood ee kala duwanaanshaha.Labadan maamule waa megakaryocyte Colony-stimulating factor (Meg CSF) iyo Thrombopoietin (TPO).Meg CSF waa cunsur nidaamin ah oo inta badan ku shaqeeya marxaladda unugyada hore, doorkeeduna waa inuu xakameeyo kororka unugyada taranka ee megakaryocyte.Marka wadarta guud ee Megakaryocyte ee dhuuxa lafta hoos u dhacdo, wax soo saarka qodobkan sharciyeynta ayaa kordha.

Ka dib marka platelets ay galaan dhiigga, waxay leeyihiin oo kaliya hawlaha jireed ee labada maalmood ee ugu horreeya, laakiin celceliska cimrigoodu wuxuu noqon karaa 7-14 maalmood.Dhaqdhaqaaqyada hemostatic physiological, platelets laftoodu way burburayaan oo sii daayaan dhammaan walxaha firfircoon ka dib marka la isku daro;Waxa kale oo laga yaabaa inay dhex gasho unugyada endothelial vascular.Marka laga soo tago gabowga iyo burburka, platelets waxa kale oo la cuni karaa inta lagu jiro hawlahooda jireed.Platelet-ka da'da ah waxa ay ku bataan beeryarada, beerka, iyo unugyada sambabada.

1. Ultrastructure of platelets

Xaaladaha caadiga ah, platelets waxay u muuqdaan sida saxanno yar oo isku dhafan oo labada dhinac ah, oo leh dhexroor celcelis ahaan 2-3 μm.Celceliska mugga waa 8 μM3.Platelets waa unugyo nukleed ah oo aan lahayn qaab dhismeed gaar ah oo hoos yimaada mikroskoob indhaha, laakiin ultrastructure kakan ayaa lagu arki karaa mikroskoob elektaroonig ah.Waqtigan xaadirka ah, qaab dhismeedka platelet wuxuu guud ahaan u qaybsan yahay agagaarka agagaarka, aagga sol gel, aagga Organelle iyo aagga nidaamka xuubabka gaarka ah.

Dusha sare ee platelet waa siman, oo leh dhismayaal yar yar oo concave ah oo muuqda, waana habdhiska kanaalka furan (OCS).Meesha ku xeeran dusha sare ee platelet waxay ka kooban tahay saddex qaybood: lakabka sare, xuubabka unugga, iyo aagga submembrane.Jaakaddu waxay inta badan ka kooban tahay glycoprotein kala duwan (GP), sida GP Ia, GP Ib, GP IIa, GP IIb, GP IIIa, GP IV, GP V, GP IX, iwm. TSP, thrombin, kolajka, fibrinogen, iwm. Waa muhiim in platelet-ka ay ka qayb qaataan xinjirowga iyo xakamaynta difaaca.Xuubka unugga, oo sidoo kale loo yaqaano xuubka balasmaha, ayaa ka kooban qaybo borotiin ah oo ku dhex jira laba-laabaha dufanka.Tirada iyo qaybinta qaybahan waxay la xiriiraan ku dheggan platelet iyo shaqada xinjirowga.Xuubku waxa uu ka kooban yahay Na+- K+- ATPase, kaas oo ilaaliya kala duwanaanshaha fiirsashada ion gudaha iyo dibadda xuubka.Aaga submembrane wuxuu ku yaalaa inta u dhaxaysa qaybta hoose ee xuubabka halbeegga iyo dhinaca dibadda ee microtubule.Aagga submembrane waxa ku jira fiilooyinka xumu-hoosaadka iyo Actin, kuwaas oo xidhiidh la leh xabagta platelet iyo isku darka.

Microtubules, microfilaments iyo fiilooyinka submembrane sidoo kale waxay ka jiraan gobolka sol gel ee platelet.Maaddooyinkaani waxay ka kooban yihiin nidaamka qalfoofka iyo foosha ee platelet, oo door muhiim ah ka ciyaara qallafsanaanta platelet, sii daynta qayb ka mid ah, kala bixida, iyo foosha.Microtubules waxay ka kooban yihiin Tubulin, oo xisaabiya 3% wadarta borotiinka platelet.Shaqadooda ugu weyn waa inay ilaaliyaan qaabka platelets.Microfilaments inta badan waxaa ku jira Actin, oo ah borotiinka ugu badan ee platelet wuxuuna xisaabiyaa 15% ~ 20% wadarta borotiinka platelet.Fiilooyinka submembrane ayaa inta badan ah qaybaha fiber-ka, kuwaas oo caawin kara borotiinka Actin-ku xidha iyo isku xirka Actin isku xidhka xidhmooyinka.Marka la eego joogitaanka Ca2 +, actin wuxuu la shaqeeyaa prothrombin, contractin, borotiinka isku xiran, co actin, myosin, iwm si loo dhamaystiro isbedelka qaabka platelet, samaynta pseudopodium, foosha unugyada iyo ficilada kale

Shaxda 1-aad ee Glycoproteins ee Membrane Platelet

Aagga Organelle waa meesha ay ka jiraan noocyo badan oo Organelle ah oo ku jira platelet, taas oo saameyn muhiim ah ku leh shaqada platelet.Sidoo kale waa goob cilmi baaris ah oo ku saabsan daawada casriga ah.Qaybaha ugu muhiimsan ee aagga Organelle waa qaybo kala duwan, sida α Particles, particles cufan (δ Particles) iyo Lysosome (λ Particles, iwm., eeg Shaxda 1 si aad faahfaahin u hesho.α Granules waa meelaha lagu kaydiyo platelets ee soo dayn kara borotiinka.Waxaa jira in ka badan toban ka mid ah unugyada platelet α.Shaxda 1 waxa ay taxaysaa oo kaliya qaybaha ugu muhiimsan, sida ku cad raadinta qoraaga, waxa la ogaaday in α ay jiraan in ka badan 230 heerar oo ah xuubka platelet derived factor (PDF) ee ku jira granules.Qaybaha cufan α Qaybaha ayaa xoogaa yar yar, dhexroorkoodu yahay 250-300nm, waxaana jira 4-8 qaybo cufan ah oo ku jira platelet kasta.Waqtigan xaadirka ah, waxaa la ogaaday in 65% ADP iyo ATP lagu kaydiyo qaybo cufan oo platelet ah, iyo 90% 5-HT ee dhiiga ayaa sidoo kale lagu kaydiyaa qaybo cufan.Sidaa darteed, qaybo cufan ayaa muhiim u ah isku-darka platelet.Awoodda lagu sii daayo ADP iyo 5-HT ayaa sidoo kale loo isticmaalaa kiliinikada si loo qiimeeyo shaqada dheecaanka platelet.Intaa waxaa dheer, gobolkani wuxuu kaloo ka kooban yahay mitochondria iyo Lysosome, oo sidoo kale ah goob cilmi baaris ah gudaha iyo dibadda sanadkan.Abaalmarinta Nobel Prize ee 2013 ee Physiology and Medicine waxaa la guddoonsiiyay saddex saynisyahano, James E. Rothman, Randy W. Schekman, iyo Thomas C. S ü dhof, si ay u ogaadaan sirta hababka gaadiidka unugyada.Waxa kale oo jira meelo badan oo aan la garanayn oo ku jira dheef-shiid kiimikaadka walxaha iyo tamarta ee platelet iyada oo loo marayo unugyada unugyada iyo Lysosome.

Aagga nidaamka xuubabka gaarka ah waxaa ka mid ah OCS iyo nidaamka tuubada cufan (DTS).OCS waa habdhiska dhuumaha tolmoonka ah ee ay sameysteen dusha sare ee platelets oo ku qulqulaya gudaha platelet, taasoo si weyn u kordhinaysa aagga dusha sare ee platelet marka ay la xiriirto balasmaha.Isla mar ahaantaana, waa kanaalka ka baxsan unugga ee walxaha kala duwan si ay u galaan platelet oo ay sii daayaan walxaha kala duwan ee platelet.Dhuumaha DTS kuma xidhna dunida ka baxsan waana meel ay ka samaysan yihiin walxaha unugyada dhiiga ku jira.

2. Shaqada Jirka ee Platelets

Shaqada ugu weyn ee jireed ee platelet waa ka qayb qaadashada hemostasis iyo thrombosis.Hawlaha shaqo ee platelets inta lagu jiro hemostasis physiological waxa loo qaybin karaa qiyaas ahaan laba marxaladood: Hemostasis bilowga ah iyo hemostasis secondary.Platelets waxay door muhiim ah ka ciyaaraan labada marxaladood ee hemostasis, laakiin hababka gaarka ah ee ay ku shaqeeyaan ayaa weli kala duwan.

1) Shaqada bilowga ah ee hemostatic ee platelet

Xididdada samaysma inta lagu guda jiro hemostasis-ka hore waa xinjirowga dhiigga cad, iyo falcelinta firfircoonida sida ku dheggan platelet, qallafsanaanta, sii daynta, iyo isku-darka ayaa ah habab muhiim u ah geeddi-socodka hemostasis aasaasiga ah.

I. falcelinta ku dheggan Platelet

Ku dhejinta udhaxeysa platelets iyo meelaha aan platelet-ka ahayn waxaa loo yaqaannaa adhesion platelet, taas oo ah talaabadii ugu horeysay ee ka qaybqaadashada falcelinta hemostatic ee caadiga ah ka dib dhaawaca xididdada dhiigga iyo tallaabo muhiim ah oo ku saabsan xinjirowga dhiigga.Dhaawaca xididdada dhiigga ka dib, platelets ee ku dhex qulqulaya markabkan ayaa lagu hawlgeliyaa dusha sare ee unugyada hoos yimaada xididdada xididada xididdada dhiigga waxayna isla markiiba u hoggaansamaan fiilooyinka kolajka ee bannaan ee goobta dhaawaca.10 daqiiqo, platelet-yada gudaha lagu shubay waxay gaareen qiimahoodii ugu badnaa, iyagoo sameeyay xinjir dhiig oo cad.

Waxyaabaha ugu muhiimsan ee ku lug leh habka isku dhejinta platelet waxaa ka mid ah xuubka xuubka glycoprotein Ⅰ (GP Ⅰ), von Willebrand factor (vW factor) iyo kolajka ku jira unugyada subendothelial.Noocyada ugu muhiimsan ee kolajka ee ku jira derbiga xididada xididada waa noocyada I, III, IV, V, VI, iyo VII, kuwaas oo ka mid ah noocyada I, III, iyo IV kolajka ayaa ah kuwa ugu muhiimsan ee habka isku dhejinta platelet ee xaaladaha qulqulaya.Cunsurka vW waa buundada isku xirta isku dhejinta platelet si ay u qorto I, III, iyo IV kolajka, iyo GP-ga gaarka ah ee glycoprotein ee xuubka xuubka platelet waa goobta ugu muhiimsan ee isku xirka platelet collagen.Intaa waxaa dheer, glycoproteins GP IIb/IIIa, GP Ia/IIa, GP IV, CD36, iyo CD31 ee xuubka platelet waxay sidoo kale ka qaybqaataan ku-xidhka kolajka.

II.falcelinta isku darka platelet

Ifafaalaha platelet-ka ee isku dheggan waxa loo yaqaan isu-ururinta.Dareen-celinta isku-darka waxay ku dhacdaa falcelinta adhesion-ka.Joogitaanka Ca2+, xuubka platelet glycoprotein GPIIb/IIIa iyo isku darka fibrinogen ee platelets oo kala firdhiyey.Isku-darka Platelet-ka waxa keeni kara laba hab oo kala duwan, mid waa kiimiko kimikal oo kala duwan, midda kalena waxa keena culayska xiirid ee xaaladaha qulqulaya.Bilawga isu-ururinta, platelets waxa ay ka beddelaan qaabka saxanka una beddelaan qaab koofiyad ah oo ka soo baxaan cago been abuur ah oo u eg qodxo yaryar;Isla mar ahaantaana, hoos u dhigista platelet waxaa loola jeedaa sii deynta walxaha firfircoon sida ADP iyo 5-HT kuwaas oo markii hore lagu kaydiyay qaybo cufan.Siideynta ADP, 5-HT iyo wax soo saarka qaar ka mid ah Prostaglandin ayaa aad muhiim ugu ah isku-darka.

ADP waa walaxda ugu muhiimsan ee isu geynta platelet, gaar ahaan ADP endogenous ee laga soo daayo platelet.Ku dar qadar yar oo ADP ah (fiirsashada 0.9) ee hakinta platelet.Haddii qiyaasaha dhexdhexaadka ah ee ADP (1.0) lagu daro μ Markay ku dhowdahay mol/L, wejiga isku-darka labaad ee aan dib loo celin karin ayaa dhacaya wax yar ka dib dhammaadka wejiga isku-darka koowaad iyo wejiga depolymerization, kaas oo ay sababto ADP endogenous ee ay sii daayaan platelets;Haddii qadar badan oo ADP ah lagu daro, waxay si dhakhso ah u keentaa isku-darka aan la bedeli karin, kaas oo si toos ah u galaya wejiga labaad ee isku-darka.Ku darista qiyaaso kala duwan oo trombobin ah oo la hakiyo platelet waxay sidoo kale keeni kartaa isku-darka platelet;Oo la mid ah ADP, marka qiyaasta si tartiib tartiib ah u korodho, isku-darka dib-u-noqoshada ayaa la arki karaa laga bilaabo kaliya wejiga koowaad ilaa muuqaalka laba weji oo isku-dar ah, ka dibna si toos ah u galaya wajiga labaad ee isku-darka.Sababtoo ah xannibaadda sii deynta ADP endogenous leh adenosine waxay joojin kartaa isu-ururinta platelet ee uu keeno thrombin, waxay soo jeedinaysaa in saameynta thrombin ay sababi karto xiritaanka thrombin ilaa receptors thrombin ee xuubka unugyada platelet, taasoo horseedaysa sii deynta ADP endogenous.Ku darida kolajka waxay sidoo kale sababi kartaa isku-darka platelet ee hakinta, laakiin kaliya isku-darka aan la bedeli karin ee wajiga labaad ayaa guud ahaan la rumeysan yahay inay sababto sii daynta endogenous ee ADP ee ay keento kolajka.Walxaha guud ahaan keeni kara isku-darka platelet-ka waxay yarayn karaan cAMP-ga platelet-ka, halka kuwa joojiya isku-darka platelet-ka ay kordhiyaan cAMP.Sidaa darteed, waxaa hadda la rumeysan yahay in hoos u dhaca cAMP uu keeni karo kororka Ca2+ ee platelet, kor u qaadista sii deynta ADP endogenous.ADP waxay sababtaa isu geynta platelet, taasoo u baahan joogitaanka Ca2+ iyo fibrinogen, iyo sidoo kale isticmaalka tamarta.

Doorka platelet Prostaglandin Fosfolipid ee xuubka balasmaha platelet waxa ku jira Arachidonic acid, unugga platelet-ka waxa ku jira Phosphatidic acid A2.Marka platelets lagu hawlgeliyo dusha sare, Phospholipase A2 sidoo kale waa la hawlgelinayaa.Iyada oo hoos timaada catalysis of Phospholipase A2, Arachidonic acid waa laga soocay fosfolipids ee xuubka balasmaha.Aashitada Arachidonic waxay samayn kartaa qadar badan oo TXA2 ah oo hoos yimaada catalysis of cyclooxygenase platelet iyo Thromboxane synthase.TXA2 waxay yaraynaysaa cAMP ee platelets, taasoo keentay isku-darka platelet iyo saamaynta vasoconstriction xooggan.TXA2 sidoo kale waa mid aan degganayn, sidaa darteed waxay si dhakhso ah isu beddeshaa TXB2 aan firfircoonayn.Intaa waxaa dheer, unugyada endothelial xididdada dhiigga ee caadiga ah waxay ka kooban yihiin prostacyclin synthase, taas oo kicin karta soo saarista prostacyclin (PGI2) ee platelet.PGI2 waxay kordhin kartaa cAMP ee platelets, sidaas darteed waxay saameyn xoog leh ku leedahay isku-darka platelet iyo Vasoconstriction.

Adrenaline waxaa la dhex mari karaa α 2. Dhexdhexaadinta adrenergic reseptor waxay keeni kartaa isku-darka platelet-ka biphasic, iyadoo xoogga la saarayo (0.1 ~ 10) μ Mol/L.Thrombin marka la joogo fiirsashada hoose (<0.1 μ Mol/L, isku-darka wejiga koowaad ee platelet-ka waxa inta badan keena PAR1; Xajmiga sare (0.1-0.3) Isku-ururinta platelet-ka waxa kale oo ka mid ah fal-celinta platelet activating factor (PAF), collagen, vW factor, 5-HT, iwm. atherosclerosis.

III.Falcelinta sii deynta platelet

Marka platelets ay la kulmaan kicinta jireed, waxay ku kaydsan yihiin qaybo cufan α Dhacdada maaddooyinka badan ee walxaha iyo lysosomes ee laga saaro unugyada waxaa loo yaqaan falcelinta sii deynta.Shaqada platelet-ka badankeeda waxaa lagu gaaraa saamaynta bayooloji ee walxaha la sameeyay ama la sii daayay inta lagu jiro falcelinta sii deynta.Ku dhawaad ​​dhammaan kiciyeyaasha keena isku-darka platelet waxay sababi karaan fal-celinta sii-deynta.Dareen-celinta sii-deynta guud ahaan waxay dhacdaa ka dib isku-darka wejiga koowaad ee platelet, iyo walaxda ay sii daayaan fal-celinta sii-deynta waxay keenaysaa isku-darka wejiga labaad.Inducers-ka sababa falcelinta sii-deynta waxa loo qaybin karaa qiyaas ahaan:

i.Inducer daciif ah: ADP, adrenaline, Norepinephrine, vasopressin, 5-HT.

ii.Inducers dhexdhexaad ah: TXA2, PAF.

iii.Inducers xooggan: thrombin, enzyme pancreatic, collagen.

2) Doorka platelets ee xinjirowga dhiigga

Platelets inta badan waxay ka qaybqaataan falcelinta xinjirowga kala duwan iyada oo loo marayo fosfolipids iyo glycoproteins xuubka, oo ay ku jiraan xayeysiinta iyo kicinta arrimaha xinjirowga (sababaha IX, XI, iyo XII), samaynta xinjirowga kor u qaadaya xuubka xuubka phospholipid, iyo kor u qaadista sameynta prothrombin.

Xuubabka balasmaha ee dusha sare ee platelet-yada ayaa ku xidhan arrimo kala duwan oo xinjirowga ah, sida fibrinogen, factor V, factor XI, factor XIII, iwm. iyo PF3 labaduba waxay kor u qaadaan xinjirowga dhiigga.PF4 waxay ka takhalusi kartaa heparin, halka PF6 ay joojiso fibrinolysis.Marka platelets lagu hawlgeliyo dusha sare, waxay dardar gelin karaan habka firfircoonida korka ee qodobbada xinjirowga ee XII iyo XI.Dusha sare ee fosfoolipid (PF3) ee ay bixiyaan platelets waxaa lagu qiyaasaa in ay dedejinayso firfircoonida prothrombin 20000 jeer.Ka dib marka la isku xiro arrimaha Xa iyo V ee dusha fosfolipid-kan, waxay sidoo kale laga ilaalin karaa saameynta xannibaadda ee antithrombin III iyo heparin.

Marka platelets ay isu geeyaan si ay u sameeyaan xinjirowga dhiigga ee dhiigga, habka xinjirowga ayaa horay uga dhacay gudaha, iyo platelets ayaa soo bandhigay xaddi badan oo sagxadaha fosfolipid ah, taas oo bixisa xaalado aad u wanaagsan kicinta factor X iyo prothrombin.Marka platelets ay kiciyaan kolajka, thrombin ama kaolin, Sphingomyelin iyo Phosphatidylcholine ee dibadda ee xuubka platelet waxay ku beddelaan phosphatidyl Ethanolamine iyo phosphatidylserine gudaha, taasoo keentay kororka fosfatidyl Ethanolamine iyo phosphatidylserine ee dusha sare.Kooxaha phosphatidyl ee kor ku xusan oo ku rogmaday dusha sare ee platelet waxay ka qaybqaataan samaynta vesicles ee dusha xuubka inta lagu jiro firfircoonida platelet.Xididdada xididadu way kala baxaan oo galaan wareegga dhiigga si ay u sameeyaan microcapsules.Vesicles iyo microcapsules waxay qani ku yihiin fosfatidylserine, taas oo ka caawisa isku dhafka iyo firfircoonida prothrombin waxayna ka qaybqaataa habka kor u qaadista xinjirowga dhiigga.

Ka dib isku-darka platelet-ka, kiisa α Sii daynta arrimaha kala duwan ee platelet ee qaybaha waxay kor u qaadaa samaynta iyo korodhka fiilooyinka dhiigga, waxayna dabinaysaa unugyada kale ee dhiigga si ay u sameeyaan xinjiro.Sidaa darteed, inkasta oo platelets ay si tartiib tartiib ah u burburaan, hemostatic emboli weli way sii kordhi karaan.Platelets-ka ku haray xinjirowga dhiigga waxay leeyihiin pseudopodia oo ku fidsan shabakadda fiber-ka dhiigga.Barootiinada qandaraaska leh ee ku jira platelet-yadan ayaa qandaraas la gala, taasoo keenaysa xinjirowga dhiigga inuu dib u gurto, tuujiyo serumka oo uu noqdo fur adag oo dhiigbaxa, si adagna u xidha farqiga xididdada dhiigga.

Marka la hawlgeliyo platelets iyo nidaamka xinjirowga ee dusha sare, waxay sidoo kale kicisaa nidaamka fibrinolytic.Plasmin-ka iyo hawlgeliyaheeda oo ku jira platelets waa la sii dayn doonaa.Siideynta serotonin ee fiilooyinka dhiigga iyo platelets waxay sidoo kale keeni kartaa unugyada endothelial si ay u sii daayaan firfircoonayaasha.Si kastaba ha ahaatee, sababtoo ah burburka platelets iyo sii deynta PF6 iyo walxaha kale ee xakameynaya proteases, ma saameeyaan dhaqdhaqaaqa fibrinolytic inta lagu jiro sameynta xinjirowga dhiigga.

(Qoddobada maqaalkan dib ayaa loo daabacay, mana bixinno dammaanad cad ama dammaanad dhab ah oo sax ah, isku halaynta ama dhammaystirnaanta waxa ku jira maqaalkan, mas'uulna kama aha fikradaha maqaalkan, fadlan fahan.)