Platelets, sida jajabyada unugyada megakaryocytes ee dhuuxa lafta, waxaa lagu gartaa maqnaanshaha nukleiyada.Platelet kastaa waxa uu ka kooban yahay saddex nooc oo qaybo ah, kuwaas oo kala ah α Granules, jidh cufan iyo lysosomes leh tiro kala duwan.Oo ay ku jiraan α Granules waxay qani ku yihiin in ka badan 300 borotiinno kala duwan, sida vascular endothelial activating factor, leukocyte chemotactic factor, factor activating, factor koritaanka la xiriira hagaajinta unugyada iyo peptide bakteeriyada, kuwaas oo ku lug leh oo badan oo nafsi ah iyo hababka pathological, sida bogsashada boogaha. , angiogenesis iyo ka hortagga caabuqa.
Jirka cufan wuxuu ka kooban yahay xaddi badan oo ah adenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2+, Mg2+ iyo 5-hydroxytryptamine.Lysosomes waxaa ku jira noocyo kala duwan oo borotiinno sonkor ah, sida glycosidases, proteases, borotiinno cationic ah iyo borotiinno leh firfircoonida bakteeriyada.GF-gan waxaa lagu sii daayaa dhiigga ka dib firfircoonida platelet.
GF waxa ay kicisaa falcelinta cascade iyada oo ku xidhaysa noocyo kala duwan oo ah soo-dhoweeyayaasha xuubka unugyada, oo waxa ay dhaqaajisaa hawlo gaar ah oo ku jira habka dib-u-soo-noolaynta unugyada.Waqtigan xaadirka ah, GF-ta ugu badan ee la bartay waa factor koritaanka platelet (PDGF) iyo isbeddelka isbeddelka koritaanka (TGF- β （TGF- β））） Unugyada koritaanka unugyada isku xiran (CTGF) iyo insulin-sida koritaanka factor-1 (IGF-1). door.
Codsiga PRP ee Vitiligo
Vitiligo, oo ah cudur caadi ah oo difaaca jirka ah, iyo sidoo kale cudurka maqaarka ee mugga daciifka ah, wuxuu saameyn xun ku leeyahay cilmi-nafsiga bukaanka wuxuuna si xun u saameeyay tayada nolosha bukaanka.Marka la soo koobo, dhacdada vitiligo waa natiijada isdhexgalka arrimaha hiddaha iyo arrimaha deegaanka, taas oo keenta melanocytes maqaarka in la weeraro oo uu dhaawaco nidaamka difaaca jirka.Waqtigan xaadirka ah, in kasta oo ay jiraan daweyn badan oo loogu talagalay vitiligo, waxtarkoodu inta badan waa mid liita, iyo daaweyno badan ayaa ka maqan caddaynta daawada caddaynta ku salaysan.Sanadihii la soo dhaafay, iyada oo sahaminta joogtada ah ee pathogenesis of vitiligo, hababka daaweynta cusub qaarkood ayaa si joogto ah loo adeegsaday.Sida hab wax ku ool ah oo lagu daweeyo vitiligo, PRP si joogto ah ayaa loo dabaqay.
Waqtigan xaadirka ah, 308 nm excimer laser iyo 311 nm ultraviolet band cidhiidhi ah (NB-UVB) iyo tignoolajiyada kale ee daaweynta sawir-qaadista ayaa si isa soo taraysa loogu aqoonsaday waxtarkooda bukaanka qaba vitiligo.Waqtigan xaadirka ah, isticmaalka cirbadeynta microneedle ee subcutaneous PRP oo ay weheliso daaweynta sawir-qaadista ee bukaannada qaba vitiligo deggan ayaa sameeyay horumar weyn.Abdelghani iyo al.Cilmi-baaris ay sameeyeen ayaa lagu ogaaday in cirbadeynta microneedle-ka-hoosaadka ee PRP oo ay weheliso daaweynta sawir-qaadista ee NB-UVB ay si weyn u gaabin karto wadarta wakhtiga daaweynta bukaannada vitiligo.
Khaddaab iyo al.waxaa lagu daweeyay bukaanada qaba vitiligo deggan oo leh 308 nm excimer laser iyo PRP, waxayna heleen natiijooyin wanaagsan.Waxaa la ogaaday in isku-darka labaduba ay si wax ku ool ah u wanaajin karaan heerka leukoplakia recolor recolor, gaabin wakhtiga daawaynta, kana fogaadaan falcelinta xun ee isticmaalka muddada-dheer ee 308 nm excimer laser irradiation.Daraasadahani waxay soo jeedinayaan in PRP oo lagu daray daaweynta sawir-qaadista ay tahay hab wax ku ool ah oo loogu talagalay daaweynta vitiligo.
Si kastaba ha ahaatee, Ibraahim iyo daraasado kale ayaa sidoo kale soo jeedinaya in PRP oo keliya aysan waxtar u lahayn daaweynta vitiligo.Kadry iyo al.waxay samaysay daraasad aan kala sooc lahayn oo ku saabsan daaweynta vitiligo oo leh PRP oo ay weheliso kaarboon-dioxide dot matrix laser, waxayna ogaatay in PRP oo lagu daray kaarboon-dioxide dot matrix laser iyo PRP oo keliya ayaa lagu gaaray saameyn dhalasho midab leh.Waxaa ka mid ah, PRP oo lagu daray kaarboon-dioxide dhibic matrix laser waxay lahayd saamaynta taranka midabka ugu fiican, PRP oo kali ah waxay ku guulaysatay taranka midabka dhexdhexaadka ah ee leukoplakia.Saamaynta taranka midabka ee PRP oo keliya ayaa ka fiicnayd tan kaarboon-dioxide dhibco matrix laser oo keliya ee daaweynta vitiligo.
Hawlgalka lagu daray PRP ee Daawaynta Vitiligo
Vitiligo waa nooc ka mid ah cilladda midabka midabka oo lagu garto midabka midabka.Hababka daawaynta caadiga ah waxaa ka mid ah daawaynta mukhaadaraadka, daawaynta sawir-qaadista ama qalliinka, ama isku-darka hababka daawaynta ee badan.Bukaannada qaba vitiligo deggan iyo saameynta xun ee daaweynta caadiga ah, daaweynta qalliinka ayaa noqon karta faragelinta ugu horreysa.
Garg iyo al.loo isticmaalo PRP sida wakiilka joojinta ee unugyada epidermal, oo loo isticmaalo Er: YAG laser si uu u shiido dhibcaha cad, taas oo ku guulaysatay saameyn daweyn oo wanaagsan oo lagu daweeyo bukaannada vitiligo deggan.Daraasaddan, 10 bukaan oo qaba vitiligo deggan ayaa la diiwaan geliyay iyo 20 nabarro ah ayaa la helay.Dhaawacyada 20, dhaawacyada 12 (60%) waxay muujiyeen soo kabasho dhamaystiran oo midab leh, 2 lesions (10%) ayaa muujiyay soo kabashada midabka weyn, 4 lesions (20%) ayaa muujiyay soo kabashada midabka dhexdhexaadka ah, iyo 2 lesions (10%) ma muujin horumar la taaban karo.Dib u soo kabashada lugaha, kala-goysyada jilibka, wejiga iyo qoorta ayaa ah kuwa ugu cadcad, halka soo kabashada xuddunta ay liidato.
Nimitha iyo al.loo isticmaalo joojinta PRP ee unugyada epidermal si loogu diyaariyo hakinta iyo joojinta fosfateerka ee unugyada epidermal si loo barbardhigo oo loo eego soo kabashada midabka ee bukaanka qaba vitiligo deggan.21 bukaan oo vitiligo deggan ayaa lagu daray 42 dhibcood oo cadcad ayaa la helay.Celceliska wakhtiga xasilloon ee vitiligo wuxuu ahaa 4.5 sano.Bukaanjiifka badankoodu waxay muujiyeen soo kabasho midab-kooban oo wareeg ah ilaa ugxan-yari qiyaastii 1-3 bilood daawaynta ka dib.Intii lagu jiray bilaha 6 ee dabagalka, celceliska soo kabashada midabku waxay ahayd 75.6% kooxda PRP iyo 65% ee kooxda PRP aan ahayn.Farqiga ka soo kabashada midabka midabka ee u dhexeeya kooxda PRP iyo kuwa aan ahayn PRP ayaa ahaa mid muhiim ah.Kooxda PRP waxay muujiyeen soo kabasho midab leh.Marka la falanqeynayo heerka soo kabashada midabka ee bukaanada qaba qaybta vitiligo, ma jirin farqi weyn oo u dhexeeya kooxda PRP iyo kuwa aan PRP ahayn.
Codsiga PRP ee Chloasma
Melasma waa nooc ka mid ah cudurrada maqaarka ee midabka midabka leh ee wajiga, kaas oo inta badan ku dhaca wajiga haweenka kuwaas oo inta badan la kulmo iftiinka ultraviolet oo leh midab maqaarka qoto dheer.Cudurkiisa si buuxda looma caddayn, wayna adagtahay in la daweeyo oo si sahlan loo soo celiyo.Waqtigan xaadirka ah, daaweynta chlorasma waxay inta badan qaadataa habka daaweynta ee la isku daray.Inkasta oo cirbadeynta subcutaneous ee PRP ay leedahay habab daaweyn oo kala duwan oo loogu talagalay chlorasma, waxtarka bukaannadu maaha mid aad loogu qanacsan yahay, wayna fududahay in ay soo noqdaan ka dib joojinta daaweynta.Iyo dawooyinka afka laga qaato sida tranexamic acid iyo glutathione waxay keeni karaan calool-xanuun caloosha, khalkhal ku yimaada wareegga caadada, madax-xanuun, iyo xitaa samaynta xididdada xididdada qotodheer ee thrombosis.
Si aad u sahamiso daawaynta cusub ee chloasma waa jihada muhimka ah ee cilmi baarista chloasma.Waxaa la sheegay in PRP ay si weyn u wanaajin karto nabarrada maqaarka ee bukaanka qaba melasma.Cay ı rl iyo et al.ayaa sheegay in haweeney 27 jir ah la siiyay cirbad-yar oo irbado hoostiisa ah oo PRP ah 15kii maalmoodba.Dhammaadka daaweynta saddexaad ee PRP, waxaa la arkay in aagga soo kabashada midabka epidermal ay ahayd> 80%, mana jirin wax soo noqnoqda 6 bilood gudahood.Sirithanabadeekul et al.loo isticmaalo PRP daaweynta chloasma si loo sameeyo RCT aad u adag, taas oo sii xaqiijisay waxtarka cirbadeynta PRP ee daawaynta chloasma.
Hofny iyo al.loo isticmaalo habka immunohistochemical si loo sameeyo TGF iyada oo loo marayo cirbadeynta microneedle subcutaneous ee PRP ee maqaarka maqaarka ee bukaanada qaba chloasma iyo qaybaha caadiga ah- β Isbarbardhigga muujinta borotiinka ayaa muujisay in kahor daawaynta PRP, nabarrada maqaarka ee bukaannada qaba chloasma iyo TGF agagaarka maqaarka maqaarka - β Muujinta borotiinka aad ayuu uga hooseeyaa kan maqaarka caafimaadka qaba (P <0.05).Daawaynta PRP ka dib, TGF ee nabarrada maqaarka ee bukaanada qaba chlorasma-β-daawaynta borotiinka ayaa si weyn u kordhay.Dhacdadani waxay muujinaysaa in saameynta hagaajinta ee PRP ee bukaannada chlorasma lagu gaari karo iyadoo la kordhinayo TGF ee nabarrada maqaarka - β Hadalka borotiinku wuxuu gaaro saameynta daaweynta ee chlorasma.
Farsamada Korontada Sawirka oo ay ku Jirto Duritaan Bukaan-jiif ah oo PRP ah oo loogu talagalay Daawaynta Chloasma
Iyadoo horumarinta joogtada ah ee tiknoolajiyada sawir-qaadista, doorka ay ku leedahay daaweynta chlorasma ayaa soo jiidatay dareen badan oo cilmi-baarayaal ah.Waqtigan xaadirka ah, laysarka loo isticmaalo daawaynta chloasma waxaa ka mid ah laser Q-switched, leysarka xargaha, iftiinka garaaca badan, laser bromide cuprous iyo tallaabooyin kale oo daaweyn ah.Mabda'a ayaa ah in qarxinta iftiinka xulashada lagu sameeyo qaybaha melanin ee gudaha ama inta u dhaxaysa melanocytes iyada oo loo marayo xulashada tamarta, iyo shaqada melanocytes waa la dhaqaajiyaa ama la xakameeyaa iyada oo loo marayo tamar yar iyo qaraxyo badan oo iftiin leh, isla mar ahaantaana, qaraxyo badan oo iftiin ah oo ah qaybaha melanin. Waa la sameeyaa, Waxay ka dhigi kartaa qaybo yaryar oo melanin ah oo ku habboon in la liqo oo uu soo saaro jirku.
Su Bifeng iyo al.Chloasma lagu daweeyay duritaanka iftiinka biyaha ee PRP oo lagu daray Q switched Nd: YAG 1064nm laser.Ka mid ah 100 bukaan oo qaba chlorasma, bukaanada 15 ee kooxda PRP + laser ayaa asal ahaan la daaweeyay, bukaanada 22 ayaa si weyn loo hagaajiyay, bukaanada 11 ayaa la hagaajiyay, iyo 1 bukaan ayaa ahaa mid aan waxtar lahayn;Kooxda laysarka oo keliya, 8 kiis ayaa asal ahaan laga daaweeyay, 21 xaaladood ayaa si muuqata waxtar u yeeshay, 18 xaaladood ayaa la wanaajiyay, 3 xaaladoodna wax tari ma laha.Farqiga u dhexeeya labada kooxood ayaa ahaa mid aad u muhiim ah (P<0.05).Peng Guokai iyo Song Jiquan waxay sii xaqiijiyeen waxtarka leysarka Q-bedeshay oo ay weheliso PRP ee daaweynta chlorasma wajiga.Natiijooyinku waxay muujiyeen in laysarka Q-bedeshay ee lagu daray PRP ay waxtar u leedahay daawaynta chlorasma wajiga
Marka loo eego cilmi-baarista hadda ee PRP ee maqaarka midabka leh, habka suurtogalka ah ee PRP ee daaweynta chlorasma waa in PRP ay kordhiso TGF ee nabarrada maqaarka- β muujinta borotiinka waxay hagaajin kartaa bukaanka melasma.Horumarinta PRP ee dhaawacyada maqaarka ee bukaanka vitiligo ayaa laga yaabaa inay la xiriirto unugyada α Adhesion molecules oo qarsoodi ah granules waxay la xiriiraan hagaajinta microevironment maxaliga ah ee dhaawacyada vitiligo by cytokines.Bilawga vitiligo wuxuu si dhow ula xidhiidha difaaca aan caadiga ahayn ee nabarada maqaarka.Daraasaduhu waxay ogaadeen in cilladaha difaaca ee maxalliga ah ee bukaannada vitiligo ay la xiriiraan fashilka keratinocytes iyo melanocytes ee maqaarka maqaarka si ay uga hortagaan dhaawaca melanocytes oo ay sababaan arrimo kala duwan oo barar ah iyo chemokines oo lagu sii daayo habka cadaadiska oksida ee intracellular.Si kastaba ha ahaatee, noocyo kala duwan oo ah arrimo koritaanka platelet oo qarsoodi ah PRP iyo noocyo kala duwan oo cytokines anti-bararka sii daayo platelet, sida burada necrosis factor reseptor I, IL-4 iyo IL-10, kuwaas oo ka soo horjeeda interleukin-1 receptor, laga yaabaa. door gaar ah ka ciyaarto nidaaminta dheelitirka difaaca deegaanka ee nabarada maqaarka.
(Qoddobada maqaalkan dib ayaa loo daabacay, mana bixinno dammaanad cad ama dammaanad dhab ah oo sax ah, isku halaynta ama dhammaystirnaanta waxa ku jira maqaalkan, mas'uulna kama aha fikradaha maqaalkan, fadlan fahan.)
Waqtiga boostada: Nov-24-2022